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Title: INFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE
Authors: OGUNBADEJO, MARIAM DAMILOLA
Ganiyu, Oboh
Keywords: INFLUENCE OF GALLIC
ACID
α-AMYLASE
α-GLUCOSIDASE
INHIBITORY AND ANTIOXIDANT
PROPERTIES OF ACARBOSE
Issue Date: Oct-2015
Publisher: FEDERAL UNIVERSITY OYE EKITI
Citation: Abella A. and Chalas J. wine on human Low-Density Lipoproteins. Atheroscl, 134, 199-206.
Series/Report no.: DEPARTMENT OF BIOCHEMISTRY PROJECT;BTH/11/0255
Abstract: Type 2 diabetes mellitus global heath and economic burden. Acarbose is an antidiabetic drug, which acts by inhibiting alpha amylase and alpha glucosidase; while gallic acid is a simple phenolic acid that is widespread in plant foods and beverages such as tea and wine.This study therefore, sought to investigate the influence of gallic acid on α-amylase and α-glucosidase inhibitory and antioxidant properties of acarbose final concentration of 25µM each. Thereafter, mixtures of the samples gallic acid; 75% acarbose + 25% gallic acid; 25% acarbose + 75% gallic acid) The results showed that the combination of 50% acarbose and 50% gallic acid showed the highest α-glucosidase inhibitory effect, while 75% acarbose + 25% gallic acid showed highest α- amylase inhibitory effect. Furthermore, all the samples caused the inhibition of Fe lipid peroxidation acarbose and 50% gallic acid causing the highest reduction in the malondialdehyde content. In addition, all the samples showed antioxidant properties radicals scavenging abilities, and Fe 2+ chelating ability acid with acarbose could be employed in the management of T2DM with the comparative advantage of possible reduction of the side effects of acarbose; nevertheless the combination of 50% acarbose and 50% gallic acid seems the best combinatory therapy for the management of type 2 diabetes mellitus.
Description: Inhibition of key enzymes associated with the hydrolysis of carbohydrate has been reported to be involved in the management of type 2 diabetes. Several diabetic complications, which have been noted to result from oxidative stress can be controlled by antioxidants. Therefore, the combinations of gallic acid with acarbose could be employed in the management of T2DM with the comparative advantage of possible reduction of the side effects of acarbose; nevertheless the combination of 50% acarbose and 50% gallic acid seems the best combinatory therapy for the management of type 2 diabetes mellitus.
URI: http://repository.fuoye.edu.ng/handle/123456789/1184
ISSN: BTH/11/0255
Appears in Collections:Department of Biochemistry Thesis

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