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| Title: | INFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE |
| Authors: | OGUNBADEJO, MARIAM DAMILOLA
Ganiyu, Oboh |
| Keywords: | INFLUENCE OF GALLIC
ACID
α-AMYLASE
α-GLUCOSIDASE
INHIBITORY AND ANTIOXIDANT
PROPERTIES OF ACARBOSE |
| Issue Date: | Oct-2015 |
| Publisher: | FEDERAL UNIVERSITY OYE EKITI |
| Citation: | Abella A. and Chalas J. wine on human Low-Density Lipoproteins. Atheroscl, 134, 199-206. |
| Series/Report no.: | DEPARTMENT OF BIOCHEMISTRY PROJECT;BTH/11/0255 |
| Abstract: | Type 2 diabetes mellitus
global heath and economic burden. Acarbose is an antidiabetic drug, which acts by inhibiting
alpha amylase and alpha glucosidase; while gallic acid is a simple phenolic acid that is
widespread in plant foods and beverages such as tea and wine.This study therefore, sought to
investigate the influence of gallic acid on α-amylase and α-glucosidase inhibitory and antioxidant
properties of acarbose
final concentration of 25µM each. Thereafter, mixtures of the samples
gallic acid; 75% acarbose + 25% gallic acid; 25% acarbose + 75% gallic acid)
The results showed that the combination of 50% acarbose and 50% gallic acid showed the
highest α-glucosidase inhibitory effect, while 75% acarbose + 25% gallic acid showed highest α-
amylase inhibitory effect. Furthermore, all the samples caused the inhibition of Fe
lipid peroxidation
acarbose and 50% gallic acid causing the highest reduction in the malondialdehyde content. In
addition, all the samples showed antioxidant properties
radicals scavenging abilities, and Fe
2+
chelating ability
acid with acarbose could be employed in the management of T2DM with the comparative
advantage of possible reduction of the side effects of acarbose; nevertheless the combination of
50% acarbose and 50% gallic acid seems the best combinatory therapy for the management of
type 2 diabetes mellitus. |
| Description: | Inhibition of key enzymes associated with the hydrolysis of carbohydrate has been
reported to be involved in the management of type 2 diabetes. Several diabetic complications,
which have been noted to result from oxidative stress can be controlled by antioxidants.
Therefore, the combinations of gallic acid with acarbose could be employed in the management
of T2DM with the comparative advantage of possible reduction of the side effects of acarbose;
nevertheless the combination of 50% acarbose and 50% gallic acid seems the best combinatory
therapy for the management of type 2 diabetes mellitus. |
| URI: | http://repository.fuoye.edu.ng/handle/123456789/1184 |
| ISSN: | BTH/11/0255 |
| Appears in Collections: | Department of Biochemistry Thesis
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