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Please use this identifier to cite or link to this item: http://repository.fuoye.edu.ng/handle/123456789/1095

Title: The effects of hyperosmolar agents lithium chloride and sucrose on the brain concentration of diminazene aceturate in rats
Authors: Asuzu, I. U
Odika, I.E
Anika, S.M.
Keywords: Sucrose; Blood-brain-barrier; Diminazene aceturate; Lithium
chloride; Trypanosomiasis
Issue Date: 5-Apr-1994
Publisher: Elsevier Science
Abstract: The concentrations of diminazene aceturate in the brain of Trypanosoma brucei brucei infected and uninfected rats treated with diminazene aceturate (3.1 mg/kg, im) and either LiC1 (2.5, 5.0 and 10 ~tg/kg) or sucrose (0.25, 0.5 and 1.0 g/kg) were determined. When diminazene aceturate was administered at a standard dose of 3.1 mg/kg (ira), the addition of LiCI (10 ~tg/kg, ira) increased significantly (P< 0.05) the concentration of the drug in the brains of both trypanosome infected and normal infected rats. The addition of sucrose (1.0 g/kg, im) instead of LiCI failed to give any significant increase in diminazene aceturate levels in the brain. The diminazene aceturate levels were significantly (P<0.05) higher in the organs (brain, kidney, liver and spleen) of trypanosome infected compared to uninfected rats. The concen- tration of diminazene aceturate in the organs increased significantly (P<0.05) with increasing concen- trations of LiC1. vc@fuoye.edu.ng
URI: http://repository.fuoye.edu.ng/handle/123456789/1095
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