http://repository.fuoye.edu.ng:80/handle/123456789/800 Thu, 16 Apr 2026 07:47:53 GMT 2026-04-16T07:47:53Z http://repository.fuoye.edu.ng:80/handle/123456789/1184 Title: INFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE Authors: OGUNBADEJO, MARIAM DAMILOLA; Ganiyu, Oboh Abstract: Type 2 diabetes mellitus global heath and economic burden. Acarbose is an antidiabetic drug, which acts by inhibiting alpha amylase and alpha glucosidase; while gallic acid is a simple phenolic acid that is widespread in plant foods and beverages such as tea and wine.This study therefore, sought to investigate the influence of gallic acid on α-amylase and α-glucosidase inhibitory and antioxidant properties of acarbose final concentration of 25µM each. Thereafter, mixtures of the samples gallic acid; 75% acarbose + 25% gallic acid; 25% acarbose + 75% gallic acid) The results showed that the combination of 50% acarbose and 50% gallic acid showed the highest α-glucosidase inhibitory effect, while 75% acarbose + 25% gallic acid showed highest α- amylase inhibitory effect. Furthermore, all the samples caused the inhibition of Fe lipid peroxidation acarbose and 50% gallic acid causing the highest reduction in the malondialdehyde content. In addition, all the samples showed antioxidant properties radicals scavenging abilities, and Fe 2+ chelating ability acid with acarbose could be employed in the management of T2DM with the comparative advantage of possible reduction of the side effects of acarbose; nevertheless the combination of 50% acarbose and 50% gallic acid seems the best combinatory therapy for the management of type 2 diabetes mellitus. Description: Inhibition of key enzymes associated with the hydrolysis of carbohydrate has been reported to be involved in the management of type 2 diabetes. Several diabetic complications, which have been noted to result from oxidative stress can be controlled by antioxidants. Therefore, the combinations of gallic acid with acarbose could be employed in the management of T2DM with the comparative advantage of possible reduction of the side effects of acarbose; nevertheless the combination of 50% acarbose and 50% gallic acid seems the best combinatory therapy for the management of type 2 diabetes mellitus. Thu, 01 Oct 2015 00:00:00 GMT http://repository.fuoye.edu.ng:80/handle/123456789/1184 2015-10-01T00:00:00Z http://repository.fuoye.edu.ng:80/handle/123456789/1183 Title: ANTIMALARIAL AND ANTIOXIDANT EFFECTS OF METHANOL AND FLAVONOID-RICH EXTRACTS OF Adansonia digitata STEM BARK ON Plasmodium berghei-INFECTED MICE Authors: OLATUNDE, MOSES DAMILOLA; Komolafe, K Abstract: Adansonia digitata has popular ethnomedicinal application in the treatment of malaria in sub-Saharan Africa. The present study sought to investigate the antimalarial and antioxidant effects of methanol and flavonoid-rich extracts of the stem bark on Plasmodium berghei-infected mice in vivo. Thirty-five male mice, weighing 18-20 g and randomly allocated into seven groups of five animals each were used. Group 1, which served as the positive control, was pretreated with 1 ml/kg of the vehicle mg/kg b.wt of the standard drugs: chloroquine and arthemter/lumfantrine respectively, groups 4 and 5 were pretreated with 200mg/kg and 400 mg/kg methanol extract of A. digitata respectively while groups 6 and 7 were administered 200mg/kg and 400 mg/kg flavonoid-rich extract of A. digitata for five consecutive days before intraperitonial transfection of mice with an inoculum size of 1x 10 7 of P.berghei. Blood was withdrawn from animals for the quantification of packed cell volume and the livers quickly excised to prepare the homogenate used to evaluate the extent of membrane lipid peroxidation and level of reduced glutathione Description: A.digitata has been investigated for its anti-inflammatory properties Caluwe et al., 2010 in the aqueous extract al., 2011) attributed to the presence of various bioactive ingredients Thu, 01 Oct 2015 00:00:00 GMT http://repository.fuoye.edu.ng:80/handle/123456789/1183 2015-10-01T00:00:00Z