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http://repository.fuoye.edu.ng:80/handle/123456789/801
2024-03-25T03:52:48ZHepatoprotective properties of Aqueous Leaf Extract of Persea americana, Mill (Lauraceae), 'Avocado' against CCl4-induced damage in Rats
http://repository.fuoye.edu.ng:80/handle/123456789/1072
Title: Hepatoprotective properties of Aqueous Leaf Extract of Persea americana, Mill (Lauraceae), 'Avocado' against CCl4-induced damage in Rats
Authors: Brai, Bartholomew; Adisa, Rahmat; Odetola, Adebimpe
Abstract: Background: Natural products from plants have received considerable attention in recent years due to their diverse pharmacological properties,
including antioxidants and hepatoprotective activities. The protective effects of aqueous extract of Persea americana (AEPA) against carbon
tetrachloride (CCl4)-induced hepatotoxicity in male albino rats was investigated.
Materials and Methods: Liver damage was induced in rats by administering a 1:1 (v/v) mixture of CCl4 and olive oil [3 ml/kg, subcutaneously (sc)]
after pre-treatment for 7 days with AEPA. Hepatoprotective effects of AEPA was evaluated by estimating the activities of alanine aminotransferase
(ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and levels of total bilirubin (TBL). The effects of AEPA on biomarkers of
oxidative damage (lipid peroxidation) and antioxidant enzymes namely, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)
and glutathione S-transferase (GST) were measured in liver post mitochondrial fraction.
Results: AEPA and Reducdyn® showed significant (p<0.05) hepatoprotective activity by decreasing the activities of ALT, AST, ALP and reducing
the levels of TBL. The activities of antioxidant enzymes, levels of malondialdehyde and protein carbonyls were also decreased dose-dependently in
the AEPA-treated rats. Pre-treatment with AEPA also decreased the serum levels of glutathione significantly.
Conclusion: These data revealed that AEPA possesses significant hepatoprotective effects against CCl4-induced toxicity attributable to its constituent
phytochemicals. The mechanism of hepatoprotection seems to be through modulation of antioxidant enzyme system.2013-01-01T00:00:00ZHypoglycemic and Hypocholesterolemic Potential of Persea americana Leaf Extracts
http://repository.fuoye.edu.ng:80/handle/123456789/1068
Title: Hypoglycemic and Hypocholesterolemic Potential of Persea americana Leaf Extracts
Authors: Brai, Bartholomew; Odetola, Adebimpe; Agomo, Philip
Abstract: The effect of aqueous and methanolic leaf extracts of Persea americana on plasma glucose, total cholesterol, low-density lipoprotein cholesterol (LDL-CHOL), and high-density lipoprotein cholesterol (HDL-CHOL) in rats was investigated. Albino rats were fed a diet containing 20% groundnut oil, 0.5% cholesterol, and 0.25% cholic acid to induce hypercholesterolemia. They were then treated daily with aqueous or methanolic extract of P. americana leaf (10 mg/kg of body weight) for 8 weeks. There were no significant (P > .05) differences in the overall body weight gain of the hypercholesterolemic rats compared to normal control. Liver to body weight ratio, plasma glucose, total cholesterol (T-CHOL), and LDL-CHOL levels were significantly (P < .05) elevated in rats fed hypercholesterolemic diet compared to normal controls. The administration of aqueous and methanolic leaf extracts of P. americana induced reductions in plasma glucose (16% and 11%,respectively), T-CHOL (8% and 5%, respectively), and LDL-CHOL (19% and 20%, respectively) in the treated rats compared to the hypercholesterolemic controls. Also, plasma HDL-CHOL concentrations increased by 85% and 68%, respectively, in the aqueous and methanolic extract-treated rats compared to the hypercholesterolemic controls. These results suggest that aqueous and methanolic leaf extracts of P. americana lower plasma glucose and influence lipid metabolism in hypercholesterolemic rats with consequent lowering of T-CHOL and LDL-CHOL and a restoration of HDL-CHOL levels. This could represent a protective mechanism against the development of atherosclerosis.2007-01-01T00:00:00Z