DSpace Collection:http://repository.fuoye.edu.ng:80/handle/123456789/8002026-04-16T07:47:53Z2026-04-16T07:47:53ZINFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSEOGUNBADEJO, MARIAM DAMILOLAGaniyu, Obohhttp://repository.fuoye.edu.ng:80/handle/123456789/11842016-02-04T13:24:27Z2015-10-01T00:00:00ZTitle: INFLUENCE OF GALLIC ACID ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE
Authors: OGUNBADEJO, MARIAM DAMILOLA; Ganiyu, Oboh
Abstract: Type 2 diabetes mellitus
global heath and economic burden. Acarbose is an antidiabetic drug, which acts by inhibiting
alpha amylase and alpha glucosidase; while gallic acid is a simple phenolic acid that is
widespread in plant foods and beverages such as tea and wine.This study therefore, sought to
investigate the influence of gallic acid on α-amylase and α-glucosidase inhibitory and antioxidant
properties of acarbose
final concentration of 25µM each. Thereafter, mixtures of the samples
gallic acid; 75% acarbose + 25% gallic acid; 25% acarbose + 75% gallic acid)
The results showed that the combination of 50% acarbose and 50% gallic acid showed the
highest α-glucosidase inhibitory effect, while 75% acarbose + 25% gallic acid showed highest α-
amylase inhibitory effect. Furthermore, all the samples caused the inhibition of Fe
lipid peroxidation
acarbose and 50% gallic acid causing the highest reduction in the malondialdehyde content. In
addition, all the samples showed antioxidant properties
radicals scavenging abilities, and Fe
2+
chelating ability
acid with acarbose could be employed in the management of T2DM with the comparative
advantage of possible reduction of the side effects of acarbose; nevertheless the combination of
50% acarbose and 50% gallic acid seems the best combinatory therapy for the management of
type 2 diabetes mellitus.
Description: Inhibition of key enzymes associated with the hydrolysis of carbohydrate has been
reported to be involved in the management of type 2 diabetes. Several diabetic complications,
which have been noted to result from oxidative stress can be controlled by antioxidants.
Therefore, the combinations of gallic acid with acarbose could be employed in the management
of T2DM with the comparative advantage of possible reduction of the side effects of acarbose;
nevertheless the combination of 50% acarbose and 50% gallic acid seems the best combinatory
therapy for the management of type 2 diabetes mellitus.2015-10-01T00:00:00ZANTIMALARIAL AND ANTIOXIDANT EFFECTS OF METHANOL AND FLAVONOID-RICH EXTRACTS OF Adansonia digitata STEM BARK ON Plasmodium berghei-INFECTED MICEOLATUNDE, MOSES DAMILOLAKomolafe, Khttp://repository.fuoye.edu.ng:80/handle/123456789/11832016-02-04T12:58:00Z2015-10-01T00:00:00ZTitle: ANTIMALARIAL AND ANTIOXIDANT EFFECTS OF METHANOL AND FLAVONOID-RICH EXTRACTS OF Adansonia digitata STEM BARK ON Plasmodium berghei-INFECTED MICE
Authors: OLATUNDE, MOSES DAMILOLA; Komolafe, K
Abstract: Adansonia digitata has popular ethnomedicinal application in the treatment of malaria in
sub-Saharan Africa. The present study sought to investigate the antimalarial and antioxidant
effects of methanol and flavonoid-rich extracts of the stem bark on Plasmodium berghei-infected
mice in vivo. Thirty-five male mice, weighing 18-20 g and randomly allocated into seven groups
of five animals each were used. Group 1, which served as the positive control, was pretreated
with 1 ml/kg of the vehicle
mg/kg b.wt of the standard drugs: chloroquine and arthemter/lumfantrine respectively, groups 4
and 5 were pretreated with 200mg/kg and 400 mg/kg methanol extract of A. digitata
respectively while groups 6 and 7 were administered 200mg/kg and 400 mg/kg flavonoid-rich
extract of A. digitata
for five consecutive days before intraperitonial transfection of mice with an inoculum size of 1x
10
7
of P.berghei. Blood was withdrawn from animals for the quantification of packed cell volume
and the livers quickly excised to prepare the homogenate used to evaluate the extent of
membrane lipid peroxidation and level of reduced glutathione
Description: A.digitata has been investigated for its anti-inflammatory properties
Caluwe et al., 2010
in the aqueous extract
al., 2011)
attributed to the presence of various bioactive ingredients2015-10-01T00:00:00Z